Comparison of 4% Succinylated Gelatin with 6% Hydroxyethyl Starch 130/0.4 for Preloading Prior to Cardiopulmonary Bypass in Coronary Artery Bypass Grafting Patients

Abstract

Aims and Objective: The present study was carried out with an objective to compare 4% succinylated gelatin with 6% hydroxyethyl starch 130/0.4 for preloading prior to cardiopulmonary bypass in coronary artery bypass grafting patients with respect to haemodynamics status, blood loss, transfusion requirement, ICU stay and complication. Methods: The study enrolling 60 patients of either sex, aged between 30-70 years undergoing elective coronary artery bypass grafting. These patients were randomly divided into two groups of 30 each. Group 1 received 500 ml 6% hydroxyethyl starch (HES) and group 2 received 500 ml 4% succinylated gelatins, on pump over a period of 25 minutes. Data were monitored included haemodynamic changes, postoperative blood loss, transfusion of PRBC and blood products, ICU stay and complications related to colloid usage. Results: We found statistically significant difference in pulse rate 5 minutes after starting colloid. Also found statistically significant difference in mean arterial pressure immediately after shifting patient to ICU but no significant difference found subsequently. There was gradual increase in CVP in both the groups but majority of patients in group 2 showed higher CVP values as compared to group 1 patients. Measured chest tube drain and output higher in starch group as compared to gelatin group, there was no need of reexploration or greater need for blood and blood products in starch group. There was no significant difference in postoperative renal parameter between two groups. Conclusions: Results of our study revealed that both the colloids i.e. 4% succinylated gelatin and 6% hydroxyethyl starch were comparable with respect to haemodynamics parameters, blood loss, transfusion requirement and complication.