Experimental evaluation of effects of a pyrimidine derivative 4CPTP on cardiovascular system

Authors

  • Prem Kumar Verma Professor and Head, Department of Pharmacology, BPS GMC for women, Khanpur Kalan, Sonepat
  • Garima Bhutani Assistant Professor, Department of Pharmacology, BPS GMC for women, Khanpur Kalan, Sonepat
  • Rahul Saini Assistant Professor, Department of Pharmacology, BPS GMC for women, Khanpur Kalan, Sonepat
  • Seema Rani Associate Professor, Department of Pharmacology, BPS GMC for women, Khanpur Kalan, Sonepat

DOI:

https://doi.org/10.7439/ijbar.v7i9.3618

Abstract

Aim: To study the effects of pyrimidine derivative 4CPTP on cardiovascular system. Material and methods: Ionotropic and chronotropic effects of 4CPTP were studied using rabbit heart and frogs heart in situ preparation. Dogs blood pressure preparation was used to assess the effects of 4CPTP on blood pressure. Results: The test compound, like phenobarbitone produced dose dependent decrease in heart rate and amplitude of contractions of rabbit and frog heart and decrease in blood pressure in dogs. Conclusions: 4 CPTP possesses negative ionotropic and negative chronotropic action along with hypotensive action in animal models.

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Published

2016-09-30

Issue

Vol. 7 No. 9 (2016): Sep

Section

Original Research Articles

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How to Cite

Experimental evaluation of effects of a pyrimidine derivative 4CPTP on cardiovascular system. (2016). International Journal of Biomedical and Advance Research, 7(9), 448-451. https://doi.org/10.7439/ijbar.v7i9.3618
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