An In-vitro study of Lipid peroxidation, Vitamin E and Vitamin C levels in saliva of oral precancerous patients in Distt Hapur of U.P.

Abstract

Objective: The objective of our study was to find out whether vitamin E and vitamins C levels in saliva can be used as a marker for cancer. Material and methods: This study was carried out in the dental OPD of Saraswathi Institute of Medical Sciences, Hapur, U.P. A total of 20 people were selected in our study, out of which 10 were normal subjects and 10 were having oral pre cancerous lesion. The saliva was collected from all the subjects. Saliva was estimated for lipid peroxidation (malondialdehyde MDA), Vitamin E and C levels respectively. Results : Our results indicated significant increase in lipid peroxidation (MDA) in oral precancerous stages but there was decrease in vitamin E and C levels. This suggests that there is an increase oxidative stress in oral precancerous lesion and may further increase in cancerous stages. Conclusion: To prevent free radical damage body has a defense system of anti oxidants which are involved in the prevention of cellular damage the common pathway for cancer ageing and a variety of diseases. From our study it was concluded that lipid peroxidation, vitamin E and C can be used as a marker for oral precancerous lesion.