Serum biomarkers for diagnosis and assessment of severity in psoriasis
DOI:
https://doi.org/10.7439/ijbar.v7i1.2868Abstract
Introduction: Psoriasis is a common inflammatory and proliferative disease of the skin. The current gold standard for assessment of extensive psoriasis has been Psoriasis Area and Severity Index (PASI). However the limitations of using PASI score in clinical practice and research necessitates for search of biomarkers. Aims and Objectives: To determine the role of serum high sensitivity C-Reactive Protein (hs-CRP), Ceruloplasmin and Malondialdehyde (MDA) as biomarkers in psoriasis and their significance in assessment of disease severity in patients with mild, moderate and severe psoriasis. Materials and Methods: The study group consisted of 120 subjects of age group 20-50 years and of both sexes. Of these 40 patients had active psoriasis with PASI score 10 (Group 2), 30 patients had active psoriasis with PASI score > 10 (Group 3) and 50 were healthy age and sex matched controls (Group 1). Results and Observations: The serum levels of CRP, ceruloplasmin and MDA are elevated in both the groups of psoriasis patients when compared to controls. The increase is statistically highly significant (p 0.001). Very large positive correlation was obtained for hs-CRP and MDA values with PASI score in both the groups, while moderate correlation was obtained for Ceruloplasmin with PASI score. Conclusion: Finally, it can be concluded that hs-CRP, MDA and Ceruloplasmin levels can be used as biomarkers and also to assess the disease severity in psoriasis.Downloads
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