Cytogenetic analysis of prostate carcinoma patients

Abstract

Background and objectives: Prostate carcinoma is the second leading cause of cancer death in men above age of 60 years worldwide. More than 80% of the cancers concomitantly arise with Benign prostate hyperplasia. Prostate carcinoma is associated with various lower urinary tract symptoms, which affect their day to day life. The aim of the present investigation was to find out the major chromosomal aberrations present in Prostate carcinoma patients and to make a comparison with other study. Methods: In present study 05 cases of prostate carcinoma were taken on the basis of clinical diagnosis from the Gujarat Cancer Research Institute (GCRI), Ahmedabad, Gujarat, India, during the period of March 2011 to October 2011. The patients were analyzed for chromosomal aberrations using cultured peripheral blood lymphocytes with their pre-informed written consent. Results: In the present study, all 5 cases were > 60 years of age. 3(60%) cases of prostate carcinoma have elevated PSA level (>4 ng/ml). In adenocarcinoma of prostate gain, deletion, and translocation of 7q22-q31 is common. In present study, Karyotype analysis reveal 01 prostate carcinoma patient had 46,XY,del(7)(q31). In present study 2 cases shows evidence of metastasis. Conclusion: Prostate carcinoma is found in > 60 years of age. Chromosome 1, 2, 3, 6, 7, 9, 16, 22, X and many more chromosomes were affected in prostate carcinoma patients, Common chromosomal aberration is 46,XY,del(7)(q31). Patients with prostate carcinoma have elevated PSA level (>4 ng/ml). Prostate carcinoma associated with metastasis have poor prognosis.