A Comparative Study Between Palonosetron and Granisetron to Prevent Post Operative Nausea and Vomiting after Gynaecological Surgery

Abstract

Aim: Our aim of this randomized and prospective clinical study was to investigate and compare the efficacy of palonosetron HCl and granisetron HCl to prevent postoperative nausea and vomiting after gynaecological surgery. Method: Fifty female patients of ASA grade I and II in between 18-60 years of age posted for elective gynaecological surgery were randomly divided into two groups containing 25 patients each. Before induction of anaesthesia group P received bolus dose of palonosetron 75 mcg and group G received bolus dose of granisetron 2.5 mg intravenously slowly over a period of 30 seconds. Result: In the postoperative period (0-3 hrs), the incidence of complete response (no postoperative nausea and vomiting, no rescue medication) was 88% with palonosetron and 76% with granisetron (p value-0.46). During 3-24 hrs postoperatively the incidence was 92% with palonosetron and 80% with granisetron (p value-0.417). During 24-48 hrs postoperatively the incidence was 92 % with palonosetron and 60 % with granisetron (p value-0.018). During 48-72 hrs incidence was statistically insignificant (p value-0.1284). Insignificant incidence of side effects between the groups was found. Conclusion: Palonosetron is more potent and long acting than granisetron for the prevention of post operative nausea and vomiting after gynaecological surgery.