Study of serum uric acid levels in acute ST elevation myocardial infarction patients and its correlation with Killips classification of heart failure

Abstract

Aims: To estimate serum uric acid levels in acute ST elevation myocardial infarction patients and its correlation with killips classification of heart failure. Methods : 100 Patients with Acute ST elevation myocardial infraction admitted between october 2011 to April 2013 were studied. Serum uric acid level was measured on day 0, 3 and 7 of MI. A detailed history and physical examination with reference to killips classification was carried out and correlated with serum uric acid levels.Statistical analysis: Data presented with mean + SD. Uric acid levels and killips class compared with spearman correlation coefficient. Results: The mean age of the patients was 58.43 + 13.77. The male to female ratio was 65:35 showing a male predominance. Mean uric acid levels on day 0 is 5.179 + 1.910, on day 3 is 5.0325 + 1.755, on day 7 is 4.953 + 1.446. Uric acid levels was compared with killip class on day 0 and it is found to be significant(r = 0.7374 and p 0.0001) and results remain significant on day 3(r = 0.5898 p 0.0001).In case of patients who expired (n = 20) the mean serum uric acid level was 6.845+2.715 and in other 80 patients was 4.783+ 1.386(t= 4.828, p 0.0001).Out of 20 patients who expired, 16 patients were having elevated serum uric acid levels(>7mg/dl). 19 patients were in Killips class IV at the time of death. On all the days serum uric acid levels were higher in patients who were in higher Killip class. Conclusion : Patients with elevated serum uric acid levels belonged to higher killips classification and were associated with higher mortality. Hence we can use serum uric acid as an inexpensive cardiovascular risk marker and prognostic marker in MI patients.