Proliferative fibrocystic lesions in association with carcinoma breast- Study of mastectomy specimens
DOI:
https://doi.org/10.7439/ijbar.v6i8.2321Keywords:
Yoga, BHT, 40 mm Hg Endurance Test, VC, FEV1, PEFRAbstract
Background: Breast cancer remains a global health problem with an increasing incidence. Proliferative breast diseases are recognized as one of the risk factors in the development of carcinoma. The study was undertaken to know the frequency of proliferative fibrocystic lesions in association with breast carcinomas in mastectomy specimens. Material and methods: The present study included 100 cases of mastectomies for carcinoma breast at Kempegowda Institute of Medical Sciences, Bangalore from August 2010 to July 2013. The tumor and the surrounding breast tissue were studied grossly and microscopically for any co-existing neoplastic and non neoplastic lesions like epithelial hyperplasia, cystic change, apocrine metaplasia, fibrosis and adenosis. Results: The study included 100 cases of breast carcinomas. The predominant type of carcinoma (85%) was infiltrating ductal carcinoma-no specific type. Proliferative breast lesions were noted in 38 cases (38%), nonproliferative breast lesions in 27 cases (27%) and there were no changes in 35 cases (35%). Of 38 cases, proliferative lesions with atypia were noted in 20 cases and proliferative lesions without atypia were noted in 18 cases. Conclusion: Proliferative lesions in the breast carry an increased risk of developing malignancies especially when there is atypia. Women, who have been diagnosed as having proliferative breast disease, require careful follow-up, with annual mammographic screening being mandatory for women with atypical hyperplasiaDownloads
References
Lap P, Tan KL, Chen B. Correlation of HER-2 status with Estrogen and Progesterone receptors and Histologic Features in 3,655 Invasive Breast Carcinomas. American Journal of Clinical Pathology 2005:123(4):541-546.
Aprino G, Laucirica R, Elledge RM. Premalignant and in situ breast disease: biology and clinical implications. Ann Intern Med.2005;143:446-457.
Schnitt SJ. Benign breast disease and breast cancer risk: morphology and beyond. Am J SurgPathol 2003;27: 836-841.
Dupont WD, Parl FF, Hartmann WH, Brinton LA, Winfield AC, Worrell JA, Schuyler PA, Plummer WD. Breast cancer risk associated with proliferative breast disease and atypical hyperplasia. Cancer 1993;71:1258-1265.
London SJ, Connolly JL, Schnitt SJ, Colditz GA. A prospective study of benign breast disease and the risk of breast cancer. JAMA February 1992;267(7):941-944.
Marshall LM, Hunter DJ, Connolly JL, Schnitt SJ et al. Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types. Cancer Epidemiol Biomarkers Prev 1997;6:297-301.
Lester SC. The Breast. In: Kumar V, Abbas AK, Fausto N, editors, Robbins and Cotran Pathologic Basis of Disease. 8th edition, Elsevier, 2010:1066-95.
Fitzgibbons PL, Henson DE, Hutter RV. Benign breast changes and the risk of subsequent breast cancer: an update of the 1985 consensus statement. Cancer Committee of the College of American Pathologists. Arch Pathol Lab Med 1998;122:1053-1055.
Bodian CA. Benign breast diseases, carcinoma in situ, and breast cancer risk. Epidemiol Rev 1993;15:177-187.
Schnitt SJ, Collins LC. Pathology of benign breast disorders. In: Harris JR, LippmanME, Morrow M, Osborne CK, editors. Diseases of the breast. New York: Lippincott Williams and Wilkins; 2009:69-85.
Precancerous Breast Disease: Epidemiological, Pathological and Clinical consideration. In Rosen
Sumeet Shah; Breast Cancer Scenario in India. Consolidated report of Population Based
Cancer Registry, 2006-2008.
Available from:URL;http://www.breastcancerindia.net/bc/statistics/stati.htm
Hartmann LC, Sellers TA, Frost MH et al. Benign Breast Disease and the Risk of Breast Cancer. N Engl J Med. July 2005;353(3):229-237.
Davis HH, Simons M and Davis JB. Cystic Disease of the Breast: Relationship to Carcinoma. Cancer. August 1964;17(8):957-978.
Sloss, P.T.; Bennett, W. A., and Clagett, O.T.: Incidence in normal breasts of features associated with chronic cystic mastitis. Am. J. Path. 1957;33:1181-1191.
Ishag MT, Baschinsky DY, Beliaeva IV et al. Pathologic Findings in Reduction Mammaplasty Specimens. Am J ClinPathol 2003;120:377-380.
McDivitt RW, Stevens JA, Lee NC et al. Histologic Types of Benign Breast Disease and the Risk for Breast Cancer. Cancer March 1992;69:1408-1414.
Ali-Fehmi R, Carolin K, Wallis T et al. Clinicopathologic Analysis of Breast Lesions Associated With Multiple Papillomas. Hum Pathol March 2003;34:234-239.
S Leibl, P Regitnig and F Moinfar. Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. Histopathology 2007;50:859-865.
Abdel-Fatah TMA, Powe DG, Hodi Z et al. High frequency of coexistence of columnar cell lesions, lobular neoplasia and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J SurgPathol March 2007;31(3):417-426.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
How to Cite
