THE EFFECT OF FOOD ON THE DISINTEGRATION TIME AND DISSOLUTION PROFILE OF ARTEMETHER-LUMEFANTRINE TABLET

Authors

  • Awofisayo Sunday Olajide Department of Clinical Pharmacy and Biopharmacy Faculty of Pharmacy, University of Uyo
  • Ekpo Kufre Michael Department of Clinical Pharmacy and Biopharmacy Faculty of Pharmacy, University of Uyo
  • Umoren Fabian James Department of Chemistry, Michael Okpara University of Agriculture, Umudike
  • Uwanta Emaime Jimmy Department of Chemistry, Akwa Ibom State University, Ikot Akpaden

DOI:

https://doi.org/10.7439/ijbar.v3i9.582

Abstract

This study aimed at comparing the release rate of artemether-lumefantrine tablets through artemether release in the presence of simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and food modified simulated gastric fluid (FMSGF) and intestinal fluid (FMSIF). Various quality control parameters including weight uniformity, tablet hardness, disintegration, friability and assay were assessed. SGF and SIF were employed as disintegration and dissolution media and compared with a food (1.3 ml full cream unsweetened evaporated milk, 2.67mg soluble starch) modified SIF and SGF (FMSIF and FMSGF) at 37

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Published

2012-10-01

Issue

Vol. 3 No. 9 (2012): Sep

Section

Original Research Articles

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How to Cite

THE EFFECT OF FOOD ON THE DISINTEGRATION TIME AND DISSOLUTION PROFILE OF ARTEMETHER-LUMEFANTRINE TABLET. (2012). International Journal of Biomedical and Advance Research, 3(9), 686-689. https://doi.org/10.7439/ijbar.v3i9.582
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