HIGH SENSITIVITY C-REACTIVE PROTEIN, PARAOXONASE 1 AND HIGH DENSITY LIPOPROTEIN CHOLESTEROL IN MYOCARDIAL INFARCTION

Abstract

Background Atherosclerosis leading to myocardial infarction is an inflammatory disease. The inflammation is caused by factors like ox-LDL, Lp(a), cytokines, triglycerides ; modified, synthesized or released in various disorders including diabetes and hypertension. The C-reactive protein (hs-CRP) is one of the markers of inflammation. The HDL is involved in reverse cholesterol transport hence HDL-C is said to be protective marker. Paraoxonase (PON1) is an HDL associated enzyme, which helps in prevention of LDL oxidation.
Objectives: The present study was carried out at Swami Ramanand Teerth Rural Medical College, Ambajogai, with an aim to find out the role of High sensitivity C-reactive protein (hs-CRP), Paraoxonase 1 (PONI) and High density lipoprotein cholesterol(HDL-C) in myocardial infarction (MI).The hs- CRP, arylesterase activity of PON1 and HDL-C were estimated in fifty diagnosed cases of myocardial infarction and were compared with fifty age and sex matched healthy controls.
Results: Serum levels of hs-CRP were significantly raised in myocardial infarction than controls [2.870.89 mg/L vs. 0.860.24 mg/L, P 0.001]. Serum PON1 activity decreased significantly in myocardial infarction as compared to healthy controls [34.0417.25 KU/L vs. 47.6316.12 KU/L, P 0.001]. Serum HDL-C levels were significantly decreased in myocardial infarction than in controls [32.286.80 vs. 28.876.40*, P 0.05].
Conclusion: The hs-CRP showed positive correlation with HDL-C (+0.301) and showed positive but weak correlation with PON1 (+0.133). No correlation was found between PON1 and HDL cholesterol.