Biochemical Activities of main Group Metal Chelates of Curcuminoid Analogues

Abstract

Turmeric and its active chemical constituents, curcuminoids, have been reported to possess a number of medicinal uses particularly in the treatment of inflammation, angiogenesis, tumorigenesis, diabetes etc. Structurally, curcuminoids are 1,7-diaryl-1,6-heptadiene-3,5-diones and are known to form metal complexes similar to other 1,3diketones. It has been reported that metal complexation of these ?, ?,-unsaturated 1,3-diketones lead to dramatic changes in their biochemical activities including antitumour, antimicrobial and antioxidant activity. The two new curcuminoid analogues namely 1,7-bis(2,5-dimethyl phenyl) hepta-1,6-diene-3,5-dione and 1,7-bis(2,4-dihydroxy phenyl)hepta-1,6-diene-3,5-dione have been synthesized and were complexed with main group metals Al(III), Ga(III) and In(III). They were characterized by IR, UV, ¹ H NMR, ¹³ CNMR and Mass spectral techniques. In vitro cytotoxic studies were done with ligand and metal complexes (Al,Ga and In) against DLA and EAC cells using Tryptan blue exclusion method and antibacterial study of the compounds were done using agar well diffusion method. The in vivo antitumour activity of the ligand and complexes were determined by using DLA cells in mice and compared with standard anticancer drug cyclophosphamide