Prevalence of Hepatitis C Virus Genotypes in Asymptomatic Blood Donors in NCT of Delhi

Authors

  • Manoj Kumar Rajput National Institute of Biologicals, NOIDA, U.P.
  • Surinder Singh National Institute of Biologicals, Noida

DOI:

https://doi.org/10.7439/ijbar.v6i4.1900

Abstract

Hepatitis C virus shows high genomic diversity which poses a challenge for drug therapy and vaccine development. Here, we present a study on prevalence of HCV genotypes and subtypes in blood donors of Delhi. Forty two HCV samples were taken from blood bags found positive at various blood banks located in Delhi. From these samples 5

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References

Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989; 244:359-62.

Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M, Murphy DG, Okamoto H, Pawlotsky JM, Penin F, Sablon E, Shin-I T, Stuyver LJ, Thiel HJ, Viazov S, Weiner AJ, Widell A. Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology. 2005; 42:962-73.

Zein NN, Rakela J, Krawitt EL, Reddy KR, Tominaga T, Persing DH. Hepatitis C virus genotypes in the United States: epidemiology, pathogenicity, and response to interferon therapy. Ann Intern Med. 1996; 125:634-9.

Takada N, Takase S, Takada A, Date T. Differences in the hepatitis C virus genotypes in different countries. J Hepatol. 1993; 17:277-83.

Messina JP, Humphreys I, Flaxman A, Brown A, Cooke GS, Pybus OG, Barnes E. Global distribution and prevalence of hepatitis C virus genotypes. Hepatology. 2015; 61:77-87.

Lole KS, Jha JA, Shrotri SP, Tandon BN, Prasad VG, Arankalle VA. Comparison of hepatitis C virus genotyping by 5' noncoding region- and core-based reverse transcriptase PCR assay with sequencing and use of the assay for determining subtype distribution in India. J Clin Microbiol. 2003; 41:5240-4.

Hissar SS, Goyal A, Kumar M, Pandey C, Suneetha PV, Sood A, Midha V, Sakhuja P, Malhotra V, Sarin SK. Hepatitis C virus genotype 3 predominates in North and Central India and is associated with significant histopathologic liver disease. J Med Virol. 2006; 78:452-8.

Singh S, Malhotra V, Sarin SK. Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in India. Indian J Med Res. 2004; 119:145-8.

Panigrahi AK, Roca J, Acharya SK, Jameel S, Panda SK. Genotype determination of hepatitis C virus from northern India: identification of a new subtype. J Med Virol. 1996; 48:191-8.

Valliammai T, Thyagarajan SP, Zuckerman AJ, Harrison TJ. Diversity of genotypes of hepatitis C virus in southern India. J Gen Virol. 1995; 76:711-6.

Chowdhury A, Santra A, Chaudhuri S, Dhali GK, Chaudhuri S, Maity SG, Naik TN, Bhattacharya SK, Mazumder DN. Hepatitis C virus infection in the general population: a community-based study in West Bengal, India. Hepatology.. 2003; 37:802-9.

Raghuraman S, Shaji RV, Sridharan G, Radhakrishnan S, Chandy G, Ramakrishna BS, Abraham P. Distribution of the different genotypes of HCV among patients attending a tertiary care hospital in south India. J Clin Virol. 2003; 26:61-9.

Amarapurkar D, Dhorda M, Kirpalani A, Amarapurkar A, Kankonkar S. Prevalence of hepatitis C genotypes in Indian patients and their clinical significance. J Assoc Physicians India. 2001; 49:983-5.

Das BR, Kundu B, Khandapkar R, Sahni S. Geographical distribution of hepatitis C virus genotypes in India. Indian J Pathol Microbiol. 2002; 45:323-8.

Pawlotsky JM. Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C. Antiviral Res. 2003; 59:1-11.

Zeuzem S. Heterogeneous virologic response rates to interferon-based therapy in patients with chronic hepatitis C: who responds less well? Ann Intern Med. 2004; 140:370-81.

Bukh J, Purcell RH, Miller RH. Importance of primer selection for the detection of hepatitis C virus RNA with the polymerase chain reaction assay. Proc Natl Acad Sci USA. 1992; 89:187-91.

Chakravarti A, Dogra G, Verma V, Srivastava AP. Distribution pattern of HCV genotypes & its association with viral load. Indian J Med Res. 2011; 133:326-31.

Zein NN. Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev. 2000; 13:223-35.

Abrignani S, Houghton M, Hsu HH. Perspectives for a vaccine against hepatitis C virus. J Hepatol. 1999; 31 Suppl 1:259-263.

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Published

2015-04-30

Issue

Section

Original Research Articles

How to Cite

Prevalence of Hepatitis C Virus Genotypes in Asymptomatic Blood Donors in NCT of Delhi. (2015). International Journal of Biomedical and Advance Research, 6(4), 323-327. https://doi.org/10.7439/ijbar.v6i4.1900