Enhancement of dissolution rate of Clofibrate BCS Class II drug by using liquisolid compact technology

Abstract

The aim of this study was to improve the dissolution rate of the poorly soluble drug Clofibrate by delivering the drug as a liquisolid compact. Liquisolid compacts were prepared using propylene glycol as solvent, Microcrystalline cellulose as carrier, Starch and Lactose are used as a coating materials. Sodium starch glycolate and Cross carmellose sodium are used as a Super disintigrants. The crystallinity of the newly formulated drug and the interaction between excipients was examined by X-ray powder diffraction and Fourier-transform infrared spectroscopy, respectively. The dissolution studies for the liquisolid formulation and the Conventional tablet were carried out at a pH 6.8 buffer. The results showed no change in the crystallinity of the drug and no interaction between excipients. The dissolution efficiency of Clofibrate at 60 min was increased from 71.02% for plain drug and 81.3% for Conventional Tablet to 100.47% for the liquisolid formulation. The increase in the dissolution rate was also found to be significant compared to the pure drug and Conventional Tablet at pH 6.8 buffer. The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like Clofibrate.