Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

Authors

  • Manisha Arora Department of Biochemistry, Muzaffarnagar Medical College, Muzaffarnagar (U.P),
  • Sudeep Kumar Department of Biochemistry, Muzaffarnagar Medical College, Muzaffarnagar (U.P),
  • Roshan Kumar Mahat Department of Biochemistry, Muzaffarnagar Medical College, Muzaffarnagar (U.P),
  • Anita Sharma Department of Biochemistry, Muzaffarnagar Medical College, Muzaffarnagar (U.P),
  • Imran Mustafa Department of Biochemistry, Muzaffarnagar Medical College, Muzaffarnagar (U.P),

DOI:

https://doi.org/10.7439/ijbar.v6i2.1678

Abstract

Background: Psoriasis is a common recurrent disease of skin characterised by excessive cell proliferation and incomplete differentiation in lesional epidermis. Aim: The present study was aimed to determine lipid parameters and paraoxonase activity in psoriatic patients. Methods: The study included 100 subjects of age group 30-60 years, out of which 50 were patients of psoriasis (Case group) and rest 50 were normal healthy individuals of same age group (Control group). Result: Our study showed significant increase (p 0.001) in the levels of Cholesterol, Triglyceride, LDL and VLDL in patients of psoriasis as compared to control group. Also, we found significant decreased levels of serum HDL and PON-1 in psoriatic patients as compared to control group. Conclusion: Our study concludes that altered lipid profile and paraoxonase may be responsible for the higher prevalence of systemic complication such as metabolic and cardiovascular diseases.

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doi: 10.1016/j.bbalip.2014.09.008.

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Published

2015-02-28

Issue

Vol. 6 No. 2 (2015): Feb

Section

Original Research Articles

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How to Cite

Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients. (2015). International Journal of Biomedical and Advance Research, 6(2), 145-148. https://doi.org/10.7439/ijbar.v6i2.1678
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