Complexation of poorly water soluble drug norfloxacin with cyclodextrin

Authors

  • Rahul Sharma Department of Pharmaceutics, N.R.I. Institute of Pharmacy, Bhopal (M.P.)
  • Ritesh S. Bathe Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola, 413307, Solapur, Maharashtra

DOI:

https://doi.org/10.7439/ijbar.v5i12.995

Abstract

The aim of the present study is to enhance the solubility and dissolution rate of poorly water soluble drug of Norfloxacin with Cyclodextrn by direct compression method. The adding a water-soluble polymer, like PVP and HPMC, with the aim to increase the aqueous solubility of both the complex and the drug itself. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F5 exhibits highest dissolution using crospovidone showed faster drug release 98.33 % over the period of 60 minutes while disintegration time of the tablet was showed 2 minutes comparison to other formulations.

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Published

2014-12-30

Issue

Vol. 5 No. 12 (2014): Dec

Section

Original Research Articles

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How to Cite

Complexation of poorly water soluble drug norfloxacin with cyclodextrin. (2014). International Journal of Biomedical and Advance Research, 5(12), 631-640. https://doi.org/10.7439/ijbar.v5i12.995
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