MICROCHIP TECHNOLOGY: A NEW APPROACH IN NOVEL DRUG DELIVERY SYSTEM

Abstract

Over the past 30 years, greater attention has been focused on development of sustained or controlled-release drug delivery system. The ideal drug-delivery system two prerequisites would require. First, it would be a single dose for the duration of treatment, whether it is for days or weeks or for the lifetime of the patient, as in diabetes or hypertension. Second, it should deliver the active entity directly to the site of action, thereby minimizing or eliminating side effects. The Micro electromechanical system (MEMS) based Implantable drug delivery system follows these criteria. MEMS technology involves integration of mechanical elements, sensors, actuators and electronic elements on common silicon subtract through microfabrication technology. Most of the existing IDDS systems have reservoirs included in the implantable system. By using sub-cutaneous port ensure biocompability and customization according to the drug requirement of the patients thus providing flexibility. This treatment requires repeated low dosage infusions over many days or months, and the comfort of the patient can be greatly involved by the use of a compact system. The dosage, infusion rate and drug combination are varied depending on the type of the clinical condition, patient response to treatment and the experience of the physician by the wireless monitoring system. The remainder of the article review the development of the controlled release microchip for drug delivery applications.