EFFECT OF ANTIOXIDANTS (VITAMIN C) ON TISSUE CERULOPLASMIN FOLLOWING RENAL ISCHEMIA REPERFUSION IN WISTAR RATS

Authors

  • Vinodini N A Kasturba Medical College,Manipal University Manipal
  • Yogesh Tripathi Santhosh Medical College,Maliwara, Nehru Nagar II, Ghaziabad 201001,Uttar Pradesh,
  • Raghuveer CV Srinivas Medical College, Mukka, Mangalore Rajivgandhi University
  • Anu Ranade Gulf Medical College
  • Asha Kamath Kasturba Medical College,Manipal University, Manipal
  • Sheila Pai Kasturba Medical College,Manipal University, Manipal

DOI:

https://doi.org/10.7439/ijbar.v3i1.269

Abstract

Aim: To study the effect of vitamin C on tissue ceruloplasmin level following renal reperfusion Materials and Methods:Wistar albino rats were divided into Group I, II and IIIThe Gr. II the experimental groups) were subjected to ischemia for 60 minutes followed by 24 hrs of reperfusion. The Gr.IIIwerepre- treated with vitamin C (20mg/kg.bw) for 30 daysfollowed by 60 minute ischemia and 24hrs of reperfusion.After the experimental procedure was over; the kidneys were removed and homogenized. The homogenized tissue was used for biochemical estimation of lipid peroxidation and ceruloplasmin Result: A significant in the levels of tissue lipid peroxidation (MDA) and increase in tissue ceruloplasmin level was observed in Group II compared to those in Group I (normal control). However, the pre- treated group (GroupIII) showed an increase in the levels of ceruloplasmin and a decrease in lipid peroxidation in comparison to group II.Conclusion: The results of the present study suggest that administration of vitamin C prior to renal ischemia reperfusion protect the renal tissue from the free radical induced reperfusion injury.

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Author Biographies

  • Vinodini N A, Kasturba Medical College,Manipal University Manipal
    Associate Professor, Department of Physiology
  • Yogesh Tripathi, Santhosh Medical College,Maliwara, Nehru Nagar II, Ghaziabad 201001,Uttar Pradesh,
    Professor, Department of Physiology
  • Raghuveer CV, Srinivas Medical College, Mukka, Mangalore Rajivgandhi University
    Professor of pathology
  • Anu Ranade, Gulf Medical College
    Assistant Professor, Department of Anatomy
  • Asha Kamath, Kasturba Medical College,Manipal University, Manipal
    Selectiongrade Lecturer, Department of Community Medicine
  • Sheila Pai, Kasturba Medical College,Manipal University, Manipal
    Professor and Head, Department of Physiology

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Published

2012-02-01

Issue

Vol. 3 No. 1 (2012): Jan

Section

Original Research Articles

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How to Cite

EFFECT OF ANTIOXIDANTS (VITAMIN C) ON TISSUE CERULOPLASMIN FOLLOWING RENAL ISCHEMIA REPERFUSION IN WISTAR RATS. (2012). International Journal of Biomedical and Advance Research, 3(1), 36-39. https://doi.org/10.7439/ijbar.v3i1.269
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