A CORRELATIVE STUDY OF ENDOMETRIAL GLYCOGEN CONTENT AND OTHER CONTRIBUTORY FACTORS ON FEMALE INFERTILITY

Abstract

Background and Objective: Endometrial glycogen is one of the most important factors for development of the blastocyst in the early stages of gestation which is reconverted into a simple monosaccharide like glucose at the time of implantation. Hence in the present study, the role of glycogen content in the endometrium and other factors like age, duration of infertility pattern of menstruation and other clinical features in causing infertility was studied. Materials and Methods: This study was carried out in the Department of Pathology, Bangalore Medical College after the ethical clearance from the institutional ethics committee. The study included 90 cases with complaints of infertility (primary / secondary). The endometrial tissue was fixed; processed, sectioned and performed Periodic Acid Schiff (PAS) stain for detecting the amount of glycogen in endometrium. The present prospective study was a descriptive study and the values are mentioned in percentages. Result: We observed that, the majority of primary infertility patients were in the age group of 21-25 years and that of secondary were in 26-30 years. Most of the patients 55(74.3%) in primary and 12(75%) had regular cycles. The duration of primary infertility group was 2-3 years and that of secondary infertility group was 4-5 years. The glycogen content in the endometrium was grossly reduced in patients with Luteal Phase Defects. Conclusion: We found that the glycogen content of endometrium was very much deficient in late secretory phase might be one of the major causes for female sterility.