Development and characterization of Omprazole loaded ethosomes for treatment of ulcer

Abstract

The current study aimed to design an oral coated solid dosage form to lower ulcer complications. The Omprazole was incorporated an ion gelation technique, with sodium alginate as the gelling agent, calcium chloride as the cross-linking agent, and chitosan as the agent for sustained release.

The optimized formulation of Omprazole showed a diameter of 2.506 mm, a swelling rate of 838.2%, and an encapsulation efficiency of 93.8%. Scanning electron microscopy images revealed the microcapsules’ spherical shape. The in vitro release of the oml from the HGMC after two hours in a simulated gastric fluid was 13.2%1±0.08%, compared with the apparent solubility of the pure omprazole under the same conditions (95.24%±3.2%). After 24 hours, the percent of omprazole released from the optimized formula was 69.84±2.4%, which indicates a sustained release pattern. The results from the in vivo study demonstrated improved healing of the induced ulcers in rats when treated with the omprazole formulation as compared to the standard omprazole therapy; therefore, the ob­tained mucoadhesive was considered a potential drug delivery strategy for ulcer therapy.