Comparative evaluation for effect of moisture activated dry granulation in tablet with conventional technique

Abstract

The purpose of undertaken project was to develop Moisture activated dry granulation (MADG) process for tablet formulation, to overcome the difficulties experienced with conventional wet granulation in terms drying, milling and substances sensitivity towards heat & moisture. For this Metoprolol succinate is used as model drug and the granulation is done by MADG and conventional wet granulation technique. The granules were prepared using spressB8 18 and prosolv SMCC 90 as an adsorbent. They have an objective of adsorbing moisture from the powder blend and redistributing it, thus eliminating one step of drying. In trial batches the effects of varying concentration of both adsorbents were explored. Granules were evaluated for parameters such as amount of fines, drying time, bulk density, compressibility, angle of repose etc. The study indicated that the granules retained their structure in comparison with the conventional process with respect to all the physicochemical parameters. In order to obtain acceptable product several trials were conducted and finally factorial batches were prepared using spressB8 18 only. The 9 formulation were prepared by varying concentration of spressb8 18 and water. The prepared granules were compressed in to tablets & they are evaluated for various pharmacopoeial evaluations like weight variation, hardness, disintegration time, friability and in-vitro dissolution. Lastly, the comparison is done between Final optimized formulation & conventional one.