Multi-wavelength Spectrophotometric Determination of Chlorzoxazone and Paracetamol in Bulk and Capsules
DOI:
https://doi.org/10.7439/ijapa.v7i2.4161Keywords:
Dexamethasone, Lignocaine, Bupivacaine, Supraclavicular Brachial Plexus BlockAbstract
A simple, cost effective spectrophotometric method has been developed for the simultaneous determination of paracetamol (PAR) and chlorzoxazone (CHL) in bulk and dosage forms. The method permits data to be taken at multiple wavelengths to generate linear plots, from which the concentrations can be determined. The absorbance values of the two analytes were linear with the concentration at the wavelengths taken at 10 nm interval over the range of 230 -300 nm. The accuracy and the precision of the developed method were very good (RSD ? 2%). The validity of the proposed method was confirmed through the statistical comparison of the obtained data with those obtained by a reference method utilizing H-point for the determination of the two actives.Downloads
References
. Sweetman S., Martindale: The Complete Drug Reference 36th ed.UK: The Pharmaceutical Press. 2009.
. Parafon Forte (McNeil). In: Krogh CME, editor. Self-Medication Product Information. 4th ed volume 2. Ottawa: Canadian Pharmaceutical Association, 1993: 130-131.
. Chatterjee P, Jain C, Sethi P. Simultaneous determination of chlorzoxazone and acetaminophen in combined dosage forms by an absorbance ratio technique and difference spectrophotometry. Journal of Pharmaceutical and Biomedical Analysis 1989; 7(6): 693-698.
. Sharaf El-Din M, Abuirjeie MA, Abdel-Hay M.H. Simultaneous determination of acetaminophen with orphenadrine citrate, ibuprofen or chlorzoxazone in combined dosage forms by zero-crossing derivative spectrophotometry. Analytical Letters 1991;
(12): 2187-2206.
. Wahbi AA, Gazy AA, Abdel-Razak O, Mahgoub H, Moneeb MS.Simultaneous Determination of Paracetamol and Chlorzoxazone using Orthogonal Functions Ratio Spectrophotometry. The Saudi Pharmaceutical Journal 2003;11(4):192-200.
. Bebawy L, El-Kousy N. Simultaneous determination of some multicomponent dosage forms by quantitative thin layer chromatography densitometric method. Journal of Pharmaceutical and Biomedical Analysis 1999; 20(4): 663-670.
. Avadhanulu AB, Pantulu ARR, Anjaneyulu Y. Gas liquid chromatographic estimation of chlorzoxazone and paracetamol in single and combined dosage forms. Indian Drugs 1994; 31(5): 201-204.
. Din
. Mohamed AM, Abu Reid IO, Alwani A. H-Point Standard Additions method for the simultaneous determination of paracetamol and chlorzoxazone in tablets using addition of both analytes and absorbance increment (?A). International Journal of Analytical Chemistry 2017; 7(1):1-5
. Blanco M, Runiaga H, Maspoch S, Tarfn P. A Simple Method for Spectrophotometric Determination of Two-Components with Overlapped Spectra. Journal of Chemical Education, 1989; 66(2): 178-180.
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