H-Point Standard Additions method for the simultaneous determination of Paracetamol and Chlorzoxazone in Tablets using addition of both analytes and absorbance increment (?A)

Authors

  • Mohammed Abdeen Mohammed Research and Development Department, Azal Pharmaceuticals, Khartoum north
  • Imad Osman Abu Reid Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al Ribat National University, Khartoum
  • Alaa Elawni Research and Development Department, Azal Pharmaceuticals, Khartoum north

DOI:

https://doi.org/10.7439/ijapa.v7i1.4006

Abstract

The suitability of H-point standard additions method (HPSAM) to resolve of overlapping spectra corresponding to the paracetamol and chlorzoxazone was verified. The results showed that the H-point standard additions method with simultaneous addition of both analytes utilizing absorbance increment is suitable for the simultaneous determination of paracetamol and chlorzoxazone. The results of applying the H-point standard additions method showed that the two drugs could be determined simultaneously with the concentration ratios of paracetamol to chlorzoxazone varying from 1:2 to 2:1 in the mixed samples. In addition the means of the calculated RSD (%) were 1.40 and 1.92 in synthetic mixtures with 1.29 and 1.68 in dosage form for paracetamol and chlorzoxazone, respectively.

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Published

2017-04-01

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Research Articles

How to Cite

1.
H-Point Standard Additions method for the simultaneous determination of Paracetamol and Chlorzoxazone in Tablets using addition of both analytes and absorbance increment (?A). Int J of Adv in Phar Ana [Internet]. 2017 Apr. 1 [cited 2025 Mar. 15];7(1):01-5. Available from: https://ssjournals.co.in/index.php/ijapa/article/view/4006