A validated stability-indicating HPLC assay method for Meclizine HCl in bulk drug

Authors

  • Milind Ubale Post-Graduate Department of Chemistry, Vasantrao Naik College, Aurangabad (MS) http://orcid.org/0000-0003-1033-8710
  • Mahesh Shioorkar Department of Chemistry, Vivekanand College, Aurangabad. (MS)
  • Vilas Choudhari Department of Chemistry, Yogeshwari College, Ambejogai. (MS)

DOI:

https://doi.org/10.7439/ijapa.v6i3.3855

Abstract

An isocratic reversed phase stability-indicating high-performance liquid chromatographic (HPLC) assay method was developed and validated for quantitative determination of Meclizine HCl in bulk drugs. An isocratic, reversed phase HPLC method was developed to separate the drug from the degradation products, using a Water Nova Pack C18 (250 x 4.6) mm, 5? column and the mobile phase containing 1.0 gm Sodium dihydrogen phosphate and 1.0 gm 1-octaneSulfonic acid salt in 1000ml water filter and mixed. Prepare a homogenous mixture of buffer, methanol and acetonitile. The detection was carried out at wavelength 264 nm. The developed method was validated with respect to linearity, accuracy (recovery), precision, system suitability, selectivity, robustness prove the stability indicating ability of the method.

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Author Biography

  • Milind Ubale, Post-Graduate Department of Chemistry, Vasantrao Naik College, Aurangabad (MS)

    Principal,

    Professor and Head,

    Post Graduate Departement of Chemistry and Research

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Published

2016-12-30

Issue

Vol. 6 No. 3 (2016): Jul-Sep

Section

Research Articles

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How to Cite

1.
A validated stability-indicating HPLC assay method for Meclizine HCl in bulk drug. Int J of Adv in Phar Ana [Internet]. 2016 Dec. 30 [cited 2026 Jan. 3];6(3):16-20. Available from: https://ssjournals.co.in/index.php/ijapa/article/view/3855
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