Quantitative UV-spectrophotometry estimation of risperidone using hydrotropic solubilization phenomenon

Authors

  • Amod Shivaji Patil Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur http://orcid.org/0000-0002-4897-8855
  • Jagruti J. Karanjavkar Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur
  • Kamil Sk. A. Khatik Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur
  • Imran Sk. D. Khatik Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur

DOI:

https://doi.org/10.7439/ijapa.v5i3.2498

Keywords:

PCOS, Heterogeneous syndrome, MFO, Androgenemia, Hyperinsulinemia, Hirsutism, BMI.

Abstract

The aim of present study was to develop simple and economical UV- pectrophotometric method for estimation of Risperidone using Area Under Curve (AUC) technique with the application of hydrotropic solubilisation phenomenon. Aqueous urea solution (30% v/v ) was used as hydrotropic agent for solubilising risperidone. The method is based upon integration of area under curve for analysis of risperidone in the wavelength range of 265.0 - 287.40 nm. The drug followed linearity in the concentration range of 4 - 24 g/mL with correlation coefficient value r 2 > 0.99. Proposed method was validated for accuracy, precision, repeatability and ruggedness as per ICH guidelines. The proposed method was applied for qualitative and quantitative estimation of risperidone in pharmaceutical formulation and results were found in good agreement with the label claimed. This developed method can be used for routine analysis of Risperidone in bulk and tablets.

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Published

2015-10-03

Issue

Vol. 5 No. 3 (2015): Jul-Sep

Section

Research Articles

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How to Cite

1.
Quantitative UV-spectrophotometry estimation of risperidone using hydrotropic solubilization phenomenon. Int J of Adv in Phar Ana [Internet]. 2015 Oct. 3 [cited 2025 Mar. 15];5(3):58-60. Available from: https://ssjournals.co.in/index.php/ijapa/article/view/2498
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