Validated RP-HPLC method for determination of related substances of montelukast from montelukast sodium chewable tablets
DOI:
https://doi.org/10.7439/ijapa.v4i2.84Abstract
The development of a RP-HPLC method for Montelukast in the presence of its impurity and degradation product generated from force degradation studies drug was exposed through various degradation stress conditions and found to be stable column used BDS Hypersil C18 (250 mm x 4.6mm) 5um. Mobile phase was used in mixture of Buffer and Acetonitrile (30:70, v/v). The HPLC method was developed and validated with respect to linearity, precession, accuracy, ruggedness and specificity.Downloads
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