Development and Validation of RP HPLC method for the estimation of Etoricoxib in bulk and tablets.

Authors

  • Hiral Satishchandra Mehta Department of Quality Assurance, Shree Devi College of Pharmacy, Airport Road, Mangalore (Karnataka)
  • Menezes Cylma Department of Quality Assurance, Shree Devi College of Pharmacy, Airport Road, Mangalore (Karnataka)
  • Akhilesh Dubey Department of Quality Assurance, Shree Devi College of Pharmacy, Airport Road, Mangalore (Karnataka)
  • Reema Narayan Department of Quality Assurance, Shree Devi College of Pharmacy, Airport Road, Mangalore (Karnataka)

DOI:

https://doi.org/10.7439/ijapa.v3i2.49

Abstract

Objective: Objective of the present analytical research work was to develop and validate Reverse Phase High Performance Liquid Chromatographic method (RP-HPLC Method) for the Etoricoxib in bulk and tablets dosage form. Methods: A RP-HPLC method has been developed and validated for estimation of ETOR in pharmaceutical oral dosage form. Method A (RP-HPLC Method): The RP-HPLC Method for Etoricoxib was developed using Shimadzu HPLC, LC-10, temperature maintained 25 0C, phenorex Gemini C18 (250 mm 4.60 mm 5?m), as stationary particle, isocratic mode. Water: ACN: OPA: TEA (40:60:0.1:0.1, v/vv/v). Mobile phase was maintained at a flow rate of 1.0 ml/min and detection was carried out at 245 nm. Results: Etoricoxib was found to be linear in the concentration range of 8 - 12 ?g/ml for RP-HPLC method. Retention time was found to be 2.7 min for Etoricoxib. The amount of Etoricoxib in marketed formulation was found to be 99.14 %. Interpretation and Conclusion: Results of assay and validation study were found to be satisfactory. So, the method can be successfully applied for the routine analysis of Etoricoxib.

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Published

2013-07-21

Issue

Vol. 3 No. 2 (2013): Apr-Jun

Section

Research Articles

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How to Cite

1.
Development and Validation of RP HPLC method for the estimation of Etoricoxib in bulk and tablets. Int J of Adv in Phar Ana [Internet]. 2013 Jul. 21 [cited 2025 Mar. 17];3(2):51-5. Available from: https://ssjournals.co.in/index.php/ijapa/article/view/1370
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