FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF METFORMIN HYDROCHLORIDE ON LABORATORY SCALE

Authors

  • Manoj S. Charde Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
  • S. Jayani Department of Pharmacy, Government Polytechnic, Amravati
  • D. Pandey Department of Pharmacy, Government Polytechnic, Amravati
  • R. D. Chakole NRI Institute of Pharmaceutical Science, Bhopal (M.P.), 462010

DOI:

https://doi.org/10.7439/ijapa.v1i2.8

Keywords:

refractive error, school children, visual acuity

Abstract

The purpose of this research is to prepare metformin hydrochloride immediate release tablets by wet granulation technique. In order to obtain the best, optimized product ten different formulations were developed. Different binder, disintegrants and lubricants taken as variables. Weight variation, thickness, hardness, friability, disintegration time, in-vitro release and pharmaceutical assay were studied as response variables. Capping was observed in formulation containing PVP K-30. However, in the remaining formulation containing PVP K-90, no capping was observed. The formulation A7 was selected as optimized formulation. The different physical properties and in-vitro release profile showed best comparable with the reference product. Optimization has proven an effective tool in product development.

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Author Biography

  • Manoj S. Charde, Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
    Assitant Professor

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Published

2011-01-01

Issue

Vol. 1 No. 2 (2011): Oct-Dec

Section

Research Articles

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How to Cite

1.
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF METFORMIN HYDROCHLORIDE ON LABORATORY SCALE. Int J of Adv in Phar Ana [Internet]. 2011 Jan. 1 [cited 2025 Mar. 15];1(2):45-7. Available from: https://ssjournals.co.in/index.php/ijapa/article/view/1344
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