Development and evaluation of enteric-coated tablets: A review
Keywords:
Enteric-coated tablets, pH-dependent polymers, delayed-release dosage forms, film coating, dissolution studies, oral drug deliveryAbstract
Enteric-coated tablets represent an important category of modified oral drug delivery systems designed to prevent drug release in the acidic environment of the stomach and allow selective release in the intestine. This dosage form is particularly beneficial for drugs that are unstable in gastric conditions, cause gastric irritation, or require site-specific intestinal absorption. The development of enteric-coated tablets involves careful selection of core tablet composition, enteric polymers, coating techniques, and evaluation methods to ensure consistent performance and regulatory compliance. Various polymers, including cellulose-based derivatives and methacrylic acid copolymers, have been extensively studied for their pH-dependent solubility and film-forming properties. Evaluation of enteric-coated tablets includes tests for acid resistance, disintegration, dissolution, stability, and release kinetics. This review provides a comprehensive overview of the principles, formulation strategies, coating technologies, polymers used, and evaluation parameters involved in the development of enteric-coated tablets, highlighting their significance in improving therapeutic efficacy, gastric tolerability, and patient compliance.
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