Formulation And Characterization of Colon Targeting Drug Delivery of Etoricoxib

Abstract

Objective: Design and development of okra gum-based colon specific tablet formulations for chrono therapeutic delivery of drugs, Eterocoxib for the treatment of diseases.

Materials and methods: The gum extracted from thoroughly washed, sliced and crushed fruits with a laboratory blender. After extraction the precipitate of the gum were dried in hot air oven for about 20min at 5⁰C and then precipitates were kept in a dessicator for further drying Etoricoxib, HPMC, E.C other formulation excipients. The in vitro dissolution test has been performed in 0.1 N HCl for first two hours and the rest in 6.8 pH phosphate buffer using USP apparatus type II (paddle), at 50 rpm for six hours. The spectrum was measured in the solid state as Potassium bromide dispersion. The Press coated tablets were prepared by varying polymer (HPMC): polymer (E.C) ratio i.e., 4:0, 3:1, 2:2, 1:3, 3:1 and 0:4.

Results and conclusion: The drug release from the dosage forms was started after 4hrs lag time. The Press coated tablets obtained by 3:1 ratio(P2F9) shows good lag time, more % drug released immediately after lag time in comparision with those prepared by4:0, 2:2, 3:1, 0:4 hence P2F9. It has been concluded from the above investigation that Press coated dosage form of Etoricoxib could delay the release up to 4hrs and further exhibited immediate release of the drug and shows 20 hr action. The results obtained in this research work clearly indicated a promising potential of colon specific drug delivery of eterocoxib by using okra gum containing HPMC, HPMS EC, as a rate controlling polymer for the effective treatment of rheumatoid patients.