A review on recent advancement in liquisolid techology

Authors

  • Abhishek Chandel Chandigarh group of colleges Ladran
  • Shaveta Sharma Chandigarh College of Pharmacy Landran, Mohali, Punjab
  • Peeyush Kaushik Chandigarh College of Pharmacy Landran, Mohali, Punjab

DOI:

https://doi.org/10.7439/ijap.v8i1.5171

Keywords:

Solubility, Absorption, Lipophlicity, Screening, bioavailability

Abstract

Liquisolid technique is a novel process in which a liquid can be converted into a material that flows freely, is readily compressible. The carrier material in liquisolid compact comprises the liquid part, which is the liquid drug or a drug solution in liquid vehicles that are non-volatile. Solubility is the main parameter in the circulation of blood to achieve the whole concentration of the drug for pharmacological action. The rate of dissolution of drugs enhances in liquisolid technology. This in turn increases absorption and bioavailability subsequently. This review discusses the different advances and changes to improve liquisolid technology formulations and enhancement of dissolution rate of poorly soluble drugs. Most of the new chemical entities have high lipophilicity and poor water solubility, resulting in poor bioavailability. The release rate of these drugs should be increased in order to improve bioavailability. The technique is based on dissolving the insoluble drug in the solution loaded with non-volatile solvent. Then the dissolution rate of drug which is poorly soluble will rise. The enhanced bioavailability is due to the increased surface area of drug for release, increased drug aqueous solubility or improved wetting capacity.

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Published

2019-06-05

How to Cite

1.
A review on recent advancement in liquisolid techology. Int J Adv Pharm [Internet]. 2019 Jun. 5 [cited 2024 Apr. 15];8(1):e5171. Available from: https://ssjournals.co.in/index.php/ijap/article/view/5171

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