Formulation, development, and evaluation of Silymarin loaded topical gel for fungal infection

Authors

  • Ankita Ashok Mojad MET's, Bhubjal Knowledge city,Institute of Pharmacy, Adgoan, Nashik.
  • Yogesh B. Khedekar Department of Pharmaceutics, MET
  • Pradip N. Malsane Department of Pharmaceutics, MET

DOI:

https://doi.org/10.7439/ijap.v8i1.5041

Keywords:

Silymarin, Topical Gel, Antipsoriasis Activity, Antifungal activity

Abstract

The objective of work was the formulation of Silymarin Loaded Topical gel obtained from the seeds of plant Silybum Marianum (L). Silymarin is a composition of flavolignan. It includes Silibinin, Silydianin, Silychristin, and isosilybinin. silymarin is used as Hepatoprotective, Antioxidant, Anticancer, Anti-Inflammatory, Anti-fibrotic, Immunomodulatory a Liver Regenerating action. It also used in viral hepatitis neuroprotective and Neurotropic action. The different type of formulation available in tablet, capsule, syrup, suspension, nanoparticles in the market. The aim of the study was to formulate and develop silymarin Loaded gel and to check its Antipsoriasis activity, with the use of Methanol as co-solvent the HPMC as Gel forming Agent and Methyl paraben and propyl paraben as Preservative. The glycerin acts as Humectant and Tween 80 used as a surfactant. The Characterization of gel such as pH, Drug content, spreadability, viscosity, in-vitro drug release was carried out in pH 6, Primary skin irritation test and antifungal activity were checked. The drug content was found to be 95.8%. Spreadability of the gel was found to be 20.66gm cm/sec. The pH of silymarin loaded gel was found to be 6.9. The silymarin loaded gel shows the pseudoplastic flow from the rheogram. It shows Drug release 96.08% over a period of 3h. There was no acute skin irritancy found.

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Author Biography

  • Ankita Ashok Mojad, MET's, Bhubjal Knowledge city,Institute of Pharmacy, Adgoan, Nashik.
    M Pharmacy Department of Pharmaceutics

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Published

2019-06-30

Issue

Section

Research Articles

How to Cite

1.
Formulation, development, and evaluation of Silymarin loaded topical gel for fungal infection. Int J Adv Pharm [Internet]. 2019 Jun. 30 [cited 2024 Apr. 15];8(1):e5041. Available from: https://ssjournals.co.in/index.php/ijap/article/view/5041

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