Formulation and in vitro study of Ibuprofen loaded crosslinked sodium alginate and gellan gum microspheres
DOI:
https://doi.org/10.7439/ijap.v6i3.4059Abstract
Ibuprofen loaded microspheres were prepared using sodium alginate and gellan gum and were cross-linked by maleic anhydride, aluminium chloride. The resulting microspheres were evaluated by in-vitro release study, swelling index, microscopic analysis and entrapment efficiency. DSC study shows there was no interaction between drug and excipients. Entrapment was found good in all the formulations while the maximum entrapment (97.6%) was recorded in formulation cross-linked by aluminium chloride and their average particle size were 150 to 160 m. Approximately 50% of drug was released by the formulation cross-linked by aluminium chloride (F2) over a period of 6 hours. From this experiment, it is observed that the formulation with cross-linked by aluminium chloride is the better formulation among others due to good release profile and entrapment efficiency.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
