Niosomes: An aproach to current drug delivery-A review
DOI:
https://doi.org/10.7439/ijap.v6i2.3863Abstract
Niosomes are a novel drug delivery system (NDDS), in which the medication is encapsulated in a vesicle. The vesicle is composed of a bilayer of non-ionic surface active agents and hence the name niosomes. The niosomes are very small, and microscopic in size. Their size lies in the nanometric scale. Although structurally similar to liposomes, they offer several advantages over them. It has been a study interest in the development of a NDDS. NDDS has an object to deliver the drug at a rate directed by the needs of the body during the period of treatment of a disease, and reach the active ingredient to the site of action. A number of NDDS have been reported through various routes of administration, to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one of the most important systems, which can be predicted to prolong the existence of the drug in systemic circulation and reduce the toxicity, if prescribed uptake can be achieved. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes, and pharmacosomes were developed. Advances have since been made in the area of vesicular drug delivery, leading to the development of systems that allow drug targeting and the sustained or controlled release of conventional medicines. The focus of this review is to the various method of preparations, characterization of niosomes, advantages and brings out the application vesicular systems.Downloads
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