In vitro ?-amylase and ?-glucosidase inhibition activity of methanolic extract of marine brown alga Spatoglossum asperum
DOI:
https://doi.org/10.7439/ijap.v4i5.2619Keywords:
Type 2 Daibetes mellitus, Streptozotocin diabetes, Alloxan diabetes, Mechanism of action of alloxan and Streptozotocin and comparison between themAbstract
The intent of the present study was to provide an in vitro evidence for potential of the marine brown alga against ?-amylase and ?-glucosidase enzymes. The methanolic extract of brown alga Spatoglossum asperum showed significant ?-glucosidase inhibitory activity of 96.75 0.03% at the concentration of 900 g/mL (IC 50 = 61 g/mL). Comparably similar effect was observed against ?-amylase with 95. 37 0.02% of inhibition (IC 50 = 55 g/mL). The above results were compared with that of the standard drug acarbose. From the above results it can be concluded that the algal extract shows an effective antidiabetic activity and indicates that Spatoglossum asperum extracts can be considered as a potential source for the management of diabetes mellitus.
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