Preparation and evaluation of mucoadhesive microspheres of repaglinide for treatment of diabetes mellitus type II

Authors

  • Arvind Parmar Department of Pharmacy, Barkatullah University
  • Ashwani Mishra Department of Pharmacy, Barkatullah University
  • Anupam Pathak Department of Pharmacy, Barkatullah University

DOI:

https://doi.org/10.7439/ijap.v4i5.2531

Abstract

Type 2 diabetes mellitus (T2DM) is the most common form of diabetes constituting 90% of the diabetic population. The number of patients with diabetes in India is currently around 40.9 million and is expected to rise to 101 million by 2030.Majority of the conventional formulations available have some drawbacks and less bioavailability, to overcome their deficiency an attempt was made to formulate mucoadhesive of Repaglinide for the treatment of Diabetes mellitus type II ,Prepared formulations were subjected for different evaluation parameters like Particle Size Analysis, Production Yield, Bulk Density, Tapped Density and Compressibility Index, Swelling Index, Mucoadhesivity study, Entrapment efficiency, Differential Scanning calorimeter and in vitro drug release study. Best formulation was chosen who passed all the evaluation parameters.

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Author Biography

  • Ashwani Mishra, Department of Pharmacy, Barkatullah University
    Assistant Professor ,Department of Pharmacy

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Published

2015-10-21

Issue

Vol. 4 No. 5 (2015): Sep-Oct

Section

Research Articles

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How to Cite

1.
Preparation and evaluation of mucoadhesive microspheres of repaglinide for treatment of diabetes mellitus type II. Int J Adv Pharm [Internet]. 2015 Oct. 21 [cited 2024 Sep. 8];4(5):72-8. Available from: https://ssjournals.co.in/index.php/ijap/article/view/2531