Non-Pressurized Topical Spray of Diclofenac Diethylamine

Abstract

The objective of research work was an attempt to develop non-pressurized topical spray formulation to improve diclofenac diethylaminepermeationthrough lipoidal membrane obstruction. A prototype formulation and thirty formulations were prepared (using different concentration of permeation enhancer, cooling, buffering, film forming agent, plasticizer and lecithin), their characterization and optimization was done (FTIR spectroscopy, drugrelease, skin-irritation, kinetics study performed by construct the plot of zero order/first order/Higuchi/KorsmeyerPeppas). A screw neck HDPE bottle procured with metered spray (200mcl) pump and actuator was selected as a dispensing system. The result demonstrated drug release of optimized formulation (F30) was found to be 93.3%3.1gcm ^-2 andits i n vitro study revealed significant plus immediate topical drug permeation. According ton>value of F30 showed super case (II) transport, erosion release mechanism, moreover no skin-irritation score.