Fabrication of gastroretentive floating swellable matrices for oral controlled and sustained release of Famotidine
DOI:
https://doi.org/10.7439/ijap.v4i4.2487Abstract
Gastroretentive (GR) swellable controlled and sustained release system of Famotidine (FMT) was formulated to increase gastric residence time of drug. A combination of Guar Gum, Psyllium Husk and Rosin were selected for the present study. Floating lag time (Flag) and diffusion exponent as dependent variables revealed that the amount of Guar Gum, Psyllium Husk and Rosin have a significant effect (p 0.05) on Famotidine release and Flag. FMTGR tablets were prepared and evaluated for weight variation, thickness, hardness, friability, drug content and floating property. Tablets were studied for dissolution for 12 h and exhibited controlled release of FMT with floating for 12 h. The release profile of the optimized batch G3 (Famotidine and Guar Gum in a ratio 1:2.5) fitted zero- -order kinetics.Downloads
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