A review on gastroretentive floating tablets of Quinapril HCl

Authors

  • Audumbar Digambar Mali Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra, India.
  • Ritesh Suresh Bathe Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra

DOI:

https://doi.org/10.7439/ijap.v3i2.2240

Abstract

Quinapril HCl is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to quinaprilat (quinapril diacid) following oral administration. Quinaprilat is a competitive inhibitor ofACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).ATIIregulates blood pressure and is a key component of the Renin-Angiotensin-Aldosterone System (RAAS). Quinapril hcl has a short biological half-life of 2 hrs with a prolonged terminal phase of 25 hours. So the floating tablet formulations are needed for Quinapril hcl to prolong its duration of action, to increase its oral bioavailability and to improve patient compliance . Many methods are used for preparing floating tablet preparations of Quinapril hcl by using various grades of Hydroxypropyl methyl celluloses (HPMC K4M, K15M, K100M) at various concentrations 10%, 20% and 30%. This review article comprises of the research materialized in the field of formulation and evaluation of floating tablets of Quinapril HCl.

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Author Biography

  • Audumbar Digambar Mali, Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra, India.
    Pharmaceutics Department and First rank in solapur university,solapur.

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Published

2014-07-09

Issue

Vol. 3 No. 2 (2014): Mar-Apr

Section

Review Article

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How to Cite

1.
A review on gastroretentive floating tablets of Quinapril HCl. Int J Adv Pharm [Internet]. 2014 Jul. 9 [cited 2024 Sep. 8];3(2):28-31. Available from: https://ssjournals.co.in/index.php/ijap/article/view/2240