In-Vitro Study of Low Viscosity, and High Viscosity Direct Compression and conventional Grade Hypromellose for Modified Release Gliclazide tablets

Authors

  • Md. Shamsuddin Sultan Khan The University of Asia Pacific, House-73, Road-5A, Dhanmondi R/A, Dhaka-1209
  • S. M. Ashraful Islam The University of Asia Pacific, House-73, Road-5A, Dhanmondi R/A, Dhaka-1209
  • Shahida Parvin Hrita Jahangirnagar University, Savar, Dhaka-1342

DOI:

https://doi.org/10.7439/ijap.v1i1.1399

Keywords:

Autoimmune disease, Leukaemia, Allogenic, Lymphomas, Bioluminescence

Abstract

Six different low to high viscosity hypromellose were used with lower soluble Gliclazide, alone to investigate the dissolution study and flow property. Dissolution behavior of formulated tablets was tested to identify the better efficacy. Dose dumping, pH dependency also was examined. Anti-diabetic Gliclazide tablets were prepared by direct compression method and the results of dissolution was found good in Methocel K100M DC for 73.25%. Tablets showed uniform weight, thickness, and lower percent ( 0.5%) friability. Result of Carrs index and Hausner ratio indicated good flow properties of powder granules. The percent release of the Gliclazide was analyzed by kinetic models. Release of the drug was higher using the higher viscosity grade. Gliclazide tablets were determined with the goodness of fit test of kinetic models. The release showed linearity in Higuchi Model with correlation coefficient value of R 2 = 0.973. In-vitro study demonstrated improved release profile using DC grade than CR grade alone.

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Author Biographies

  • Md. Shamsuddin Sultan Khan, The University of Asia Pacific, House-73, Road-5A, Dhanmondi R/A, Dhaka-1209
    Department of Pharmacy,
  • S. M. Ashraful Islam, The University of Asia Pacific, House-73, Road-5A, Dhanmondi R/A, Dhaka-1209
    Department of Pharmacy,
  • Shahida Parvin Hrita, Jahangirnagar University, Savar, Dhaka-1342
    Department of Pharmacy,

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Published

2013-01-01

Issue

Vol. 1 No. 1 (2012): Nov- Dec

Section

Research Articles

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How to Cite

1.
In-Vitro Study of Low Viscosity, and High Viscosity Direct Compression and conventional Grade Hypromellose for Modified Release Gliclazide tablets. Int J Adv Pharm [Internet]. 2013 Jan. 1 [cited 2025 Jul. 26];1(1):09-15. Available from: https://ssjournals.co.in/index.php/ijap/article/view/1399
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